Assuntos
Infecções por Coronavirus , Pandemias , Papaína , Pneumonia Viral , Síndrome Respiratória Aguda Grave , Betacoronavirus , COVID-19 , Humanos , Imunidade Inata , SARS-CoV-2RESUMO
COVID-19 has emerged as one of the worst pandemics in recent history and has exposed the weaknesses of healthcare systems worldwide. Here, we reflect on the lessons learned from a year in a pandemic. We discuss the extraordinary scientific advances made in our understanding of a new disease, the failed and successful attempts to halt its progression, and the impact of the pandemic on the scientific discourse within the global community.
Assuntos
Pesquisa Biomédica , COVID-19/epidemiologia , COVID-19/metabolismo , Pandemias , SARS-CoV-2/metabolismo , COVID-19/patologia , COVID-19/terapia , HumanosRESUMO
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.